for Physicians
for Patients

Thrombotic microangiopathies

Observational study on epidemiological data in STEC-HUS patients reported in ERKReg

Name of Principal Investigator and research fellow mentor: Prof Dr Nicole van de Kar

Affiliation: Radboudumc

An infection with a Shiga toxin producing E.coli can lead to hemolytic uremic syndrome (HUS). Shiga toxin 2 producing E.coli strains are the most virulent serotypes, especially serotype O157 , and knwon to cause the hemolytic uremic syndrome in childhood.
Early identification of STEC infection, especially the known high risk serotypes profiles, is important for case management of STEC infections and STEC-HUS.

STEC infections and STEC-HUS are so called zoonotic diseases, meaning that the bacteria is transmissible from animals to humans. In the European union have a system for monitoring and collecting information on these bacteria and their causing diseases in humans. In the EFSA report from 2022 for STEC infections it is reported that Shiga toxin type 2 is the most reported virulence factor in human disease. Seroptype O157 is the most seen pathogen in STEC-HUS worldwide, however in Europe the most reported serotype is O26.

  1. Epidemiology characterization of the STEC-HUS population in ERKReg
  2. Which serotype is reported in the ERKreg registry found in STEC-HUS ?
  3. Is the shiga toxin type known?
  4. Are the epidemiology data in STEC-HUS patients in Europe matching the data in EFSA report?
  5. Questionnaire for the expertise centers about the laboratory strategies used to define STEC infection

STEC-HUS patients reported in ERKReg

  • they have an orphan code
  • children and adults

Data Sources: ERKReg, surveys & HCP centre data

 

Data Elements:

  • Observational study on epidemiological data STEC-HUS patients reported in ERKReg (clinical data and laboratory data)
  • Survey to ERKnet centers on laboratory diagnostic methods used to detect STEC bacteria
  • Observational study
  • Survey online