ERKNet

The European Rare Kidney Disease Reference Network

  

Research Project

Project Title:

HPVaxResponse Study

Project Type:

Observational Study, Enrolment ongoing
Adjunct biobank: Serum

Disease group(s):

Pediatric kidney transplantation

Project Summary:

Due to their immunosuppressive therapy, solid-organ transplant (SOT) recipients bear a 10 to 100 times higher risk of human papillomavirus (HPV)-associated malignancies than healthy individuals. The objectives of this observational, non-interventional multi-national, multi-centre research project are to gain an insight into current HPV vaccination strategies and to investigate the immune response to different routinely administered HPV vaccines in European paediatric SOT candidates and immunocompromised transplant recipients, enabling patients at risk of vaccination failure to be identified. Type-specific neutralising antibody titres will be analysed by use of a high-throughput, pseudovirion-based HPV neutralisation assay. Quantification and avidity of vaccine-induced HPV-L1 antibodies are intended to be assessed by multiplex serology. The study will be conducted within the already existing European cooperative research network for paediatric kidney transplantation (CERTAIN, www.certain-registry.eu) and paediatric liver transplantation (CERTAIN-LI, www.certainli-registry.eu), both of which have been initiated by the paediatric transplant research working group at the University Children’s Hospital Heidelberg.

Lead principal investigator(s):

Britta Hoecker, Heidelberg
Burkhard Toenshoff, Heidelberg
Nicholas Webb, Manchester

Co-investigator(s):

Julia Tabatabai, Heidelberg
Michael Pawlita, Heidelberg

Project Period:

03/2017   -   12/2018

Sponsors:

Local resources

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