ERKNet

The European Rare Kidney Disease Reference Network

  

Research Project

Project Title:

Assessing calcium balance in children with chronic kidney disease to optimise treatment strategies

Project Type:

Observational Study, Enrolment ongoing
Adjunct biobank: Serum, Urine

Disease group(s):

Pediatric CKD & dialysis

Project Summary:

We propose a novel technique of Ca isotope fractionation to determine calcium balance. Ca isotope fractionation (expressed as δ44/40Ca) will be measured by thermal ionisation massspectrometry in diet, blood, urine and faeces, and described as net Ca gain or loss using a compartment model based on Ca kinetics. The percentage bone gain (or loss) can be determined, and annualized change in BMD calculated. δ44/40Ca values will be correlated with BMD (measured by peripheral quantitative CT and dual-energy x-ray absorptiometry) and bone-specific biomarkers. The Ca isotope fractionation technique will provide a powerful tool to guide therapy in CKD patients so as to prevent Ca deficiency and fractures or Ca overloading and cardiovascular disease.

Lead principal investigator(s):

Rukshana Shroff, London

Co-investigator(s):

Claus Peter Schmitt, Heidelberg
Justine Bacchetta, Lyon
Dieter Haffner, Hannover

Project Period:

01/2017   -   12/2019

Sponsors:

Non-profit foundation, National funding agency

ClinicalTrials.gov:

CDF-2016-09-038

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