ERKNet

The European Rare Kidney Disease Reference Network

  

Research Project

Project Title:

Urinary Biomarkers: Analysis of Urine in patients with tubular and glomerular kidney disease

Project Type:

Translational research

Disease group(s):

Hereditary glomerulopathies, Immune glomerulopathies, Tubulopathies, Metabolic & stone disorders, Thrombotic microangiopathies, AD structural kidney disorders, Renal malformations, Obstructive nephropathies, Pediatric CKD & dialysis, Pediatric kidney transplantation

Project Summary:

Kidney diseases lead to a change in urinary composition since the urine virtually passes all segments of the nephron. This is the case for nucleic acids and proteins as well as metabolites of aerobic and anaerobic metabolism. Until now this fact is only used insufficiently in monitoring and diagnosing renal diseases. One patient group that may highly profit from novel urinary diagnostic markers are transplanted patients. On the one hand the underlying disease that led to ESRD in the first place (e.g. FSGS) can recur in the transplant. Current urinary markers like proteinuria are rather unspecific and allow no conclusion as to the cause of kidney function impairment. Apart from recurrence of the underlying disease a number of other causes of renal function loss are possible including acute kidney injury, drug toxicity and rejections. In the end a kidney biopsy is nearly always required to make a clear diagnosis; however, even the biopsy with its sampling error may not answer all questions. Consequently, novel diagnostic markers would be highly valuable. We aim to identify such markers by analyzing urine, the components of which reflect the status of the entire kidney or transplant.

Lead principal investigator(s):

Roman-Ulrich Mueller, Cologne

Co-investigator(s):

Max Liebau, Cologne
Sandra Habbig, Cologne
Lutz Weber, Cologne
Franziska Grundmann, Cologne
Fabian Braun, Cologne
Dirk Stippel, Cologne
Roger Wahba, Cologne
Denise Buchner, Cologne

Project Period:

10/2012   -   09/2042

Sponsors:

Non-profit foundation, Regional funding agency, Local resources

Project web page:

https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00010534

ClinicalTrials.gov:

DRKS00010534

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