The European Rare Kidney Disease Reference Network


Research Project

Project Title:

Impact on Neurocognitive Performance in Children, Adolescents and Young Adults of CKD and its Therapy (the INPACT study)

Project Type:

Observational Study, Enrolment ongoing

Disease group(s):

Pediatric CKD & dialysis

Project Summary:

We aim to unravel the extent and nature of cognitive impairment in CAYAs with (pre-)end-stage renal disease (CKD 4-5/ESRD), and its impact on everyday functioning and well-being. We will use a WHO-adopted bio-psycho-social framework which allows us to systematically study the impact of CKD 4-5/ESRD on cognitive functioning, along the whole continuum: from brain imaging techniques, via neuropsychological testing to everyday functioning and well-being. We also aim to analyze the effect of different modes of renal replacement therapy (dialysis, and preemptive vs. non-preemptive transplantation) on cognition. The contribution of sociodemographic factors and ‘normal development’ will be taken into account by including a healthy control sample.
Current study is a pilot study

Lead principal investigator(s):

Jaap Groothoff, Amsterdam
Kim Oostrom, Amsterdam
Marit van Sandwijk, Amsterdam


Marc Lilien, Utrecht
Koen Vanhoeck, Antwerp
Noel Knops , Leuven
Linda Koster, Nijmegen
Ann Raes, Ghent
Christina Taylan, Cologne
Bernd Hoppe , Bonn
Karlien Cransberg, Rotterdam
Frederike Bemelman, Amsterdam

Project Period:

05/2017   -   12/2018


Non-profit foundation

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