Observational study on epidemiological data in STEC-HUS patients reported in ERKReg
Name of Principal Investigator and research fellow mentor: Prof Dr Nicole van de Kar
Affiliation: Radboudumc
An infection with a Shiga toxin producing E.coli can lead to hemolytic uremic syndrome (HUS). Shiga toxin 2 producing E.coli strains are the most virulent serotypes, especially serotype O157 , and knwon to cause the hemolytic uremic syndrome in childhood.
Early identification of STEC infection, especially the known high risk serotypes profiles, is important for case management of STEC infections and STEC-HUS.
STEC infections and STEC-HUS are so called zoonotic diseases, meaning that the bacteria is transmissible from animals to humans. In the European union have a system for monitoring and collecting information on these bacteria and their causing diseases in humans. In the EFSA report from 2022 for STEC infections it is reported that Shiga toxin type 2 is the most reported virulence factor in human disease. Seroptype O157 is the most seen pathogen in STEC-HUS worldwide, however in Europe the most reported serotype is O26.
STEC-HUS patients reported in ERKReg
Data Sources: ERKReg, surveys & HCP centre data
Data Elements: