Research Project

Project Title:	International Peritoneal Biobank
Project Type:	Observational Study, Enrolment ongoing Adjunct biobank: DNA, Serum, Plasma
Disease group(s):	Pediatric CKD & dialysis, Pediatric kidney transplantation
Project Summary:	Within a few years of peritoneal dialysis (PD) the peritoneum undergoes major morphological and functional alterations, which ultimately result in PD failure. PD purification efficiency is limited, and PD patients suffer from rapidly progressing vascular disease. The International Peritoneal Biobank collects parietal peritoneal and omental specimen from patients with normal renal function, CKD5, PD with different PD fluids and following renal transplantation across all age groups (0-70 years), together with blood, dialysate and clinical data. CKD5, PD and Tx related local and systemic pathomechanisms of tissue transformation and vasculopathy. Arteriolar transcriptome and proteome regulation and omental metabolome is analysed in all groups and supplemented by suitable in vitro and in vivo models. The biobank aims at comprehensive understanding of the molecular machineries, and provides detailed information for targeted validation studies and (experimental) therapeutic interventions. Studies on peritoneal transport mechanisms aim at improving PD efficacy and sustainability but also at understanding systemic disease and identification of potential therapeutic targets.
Lead principal investigator(s):	Claus Peter Schmitt, Heidelberg
Co-investigator(s):	Betti Schäfer, Heidelberg
Project Period:	01/2011 - 01/2050
Sponsors:	Industry, Local resources
Project web page:	http://www.pedpd.org/
ClinicalTrials.gov:	NCT01893710

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